Find your way out of depression with ketamine treatment
We offer esketamine (Spravato) treatment for people living with depression who have not found enough relief with traditional medications. It works differently in the brain and may help improve mood, energy, and emotional clarity more quickly than standard antidepressants.
Our program provides safe, closely monitored ketamine care in a comfortable outpatient setting, along with ongoing clinical support.
How ketamine helps with depression.
The exact mechanism of action of Spravato® in treating depression is not fully understood, but it is believed to involve modulation of glutamate signaling in the brain.
Glutamate is the most abundant neurotransmitter in the brain and is involved in various brain functions, including learning, memory, and mood regulation. By targeting the NMDA receptor, Spravato® may help restore balance to glutamate signaling, leading to improvements in mood and cognition.
Spravato® is administered as a nasal spray under the supervision of a healthcare provider in a certified treatment center. The dosage and frequency of treatment vary depending on individual response and tolerability. Typically, you may receive Spravato® twice weekly for the first four weeks, followed by maintenance doses as needed. Each treatment session lasts approximately two hours, including monitoring for side effects.
Week 1–4: Two treatments per week
Week 5–8: One treatment per week
Week 9+: Maintenance doses as needed
Considerations for Use
Spravato® is indicated for use in adults with TRD who have not responded adequately to other treatments. It is not intended as a first-line therapy for depression and should be reserved for patients who have exhausted other options.
Before initiating treatment with Spravato®, healthcare providers should conduct a comprehensive assessment to determine the appropriateness of the treatment and discuss potential risks and benefits of Spravato for treatment of depression with you.
What to Expect During Treatment
Administration: Spravato® is a nasal spray that you self-administer in our office under medical supervision.
Observation: You’ll relax in a private, comfortable space for about 2 hours while our clinical team monitors you for safety and side effects.
After Treatment: Because Spravato® can cause temporary drowsiness or dizziness, you’ll need a responsible adult to drive you home after each session. Most patients can resume normal activities the next day.
Effectiveness
Clinical studies show that Spravato® (esketamine) can help reduce depression symptoms in people who have not felt better with traditional antidepressants. When used together with an oral antidepressant, many patients experience greater improvement than with standard treatment alone. In research studies, some people noticed relief within hours or days after treatment, rather than waiting weeks. This faster response can be especially meaningful for those who have been struggling with long-lasting or severe depression and need more immediate support.
Safety & Side Effects
While Spravato® has shown promise as a treatment for TRD, it is not without risks. The most common side effects reported during clinical trials include dissociation, dizziness, nausea, sedation, and increased blood pressure. As a result, patients must be monitored closely during and after treatment sessions to ensure their safety. Additionally, due to the risk of dissociation and sedation, you are advised not to drive or operate heavy machinery for the remainder of the day after receiving Spravato®.
Our Certification
Amazing Grace Center is certified by the Risk Evaluation & Mitigation Strategy (REMS) to provide to provide Spravato for treatment resistant depression .
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We’re here to help without judgement.