If you’re considering Spravato® (esketamine) for treatment-resistant depression, cost is probably one of your first questions. The numbers you find online can be intimidating, but they rarely tell the whole story. Without insurance, Spravato treatment can cost several thousand dollars during the first month. Fortunately, most patients don’t pay the full retail price. Because Spravato is FDA-approved, many private insurance plans, Medicare, and Ohio Medicaid provide coverage for eligible patients. This guide explains what Spravato costs, what insurance typically covers, and how financial assistance programs may help reduce your out-of-pocket expenses.